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Abstract: Overpressure is significant to the exploration and exploitation of petroleum due to its influence on hydrocarbon accumulation and drilling strategies. The deep-burial hydrocarbon reservoirs of Jurassic strata in the central Junggar Basin are characterized by intensive overpressure, whose origins are complex and still unclear. In this study, Bowers’ method and sonic velocity-density crossplot method based on well logging data were used as a combination for overpressure judgements in geophysics. Furthermore, the corresponding geological processes were analysed in quality and quantity to provide a rational comprehension of the overpressure origins and the model of overpressure evolution and hydrocarbon accumulation processes. The results showed that hydrocarbon generation in the Jurassic source rocks led to overpressure in the mudstones, while hydrocarbon generation in Permian source rocks led to overpressure in the sandstone reservoirs in Jurassic strata by vertical pressure transfer. The burial and thermal history indicated that the aquathermal effect of pore fluids by temperature increase in deep strata is also an important origin of overpressure, while disequilibrium compaction may not be the dominant cause for the overpressure in deep-buried strata. Furthermore, the continuous tectonic compression in both the north–south and west-east trends from the Jurassic period to the present may also have enhanced the overpressure in deep strata. Meanwhile, the developed faults formed by intensive tectonic compression led to pressure transfer from source rocks to the Jurassic reservoirs. Overpressured geofluids with hydrocarbons migrated to sandstone reservoirs and aggravated the overpressure in the Jurassic strata. To conclude, the intensive overpressure in the central Junggar Basin is attributed to the combination of multiple mechanisms, including hydrocarbon generation, the aquathermal effect, tectonic compression and pressure transfer. Furthermore, the developed overpressure indicated hydrocarbon migration and accumulation processes and the potential of oil and gas reservoirs in deeply buried strata. We hope this study will provide a systematic research concept for overpressure origin analysis and provide guidance for petroleum exploration and exploitation in deep-buried strata.